Ethacridine inhibits SARS-CoV-2 by inactivating viral particles
  Xiaoquan Li, Peter Lidsky, Yinghong Xiao, Chien-Ting Wu, Miguel Garcia-Knight, Junjiao Yang, Tsuguhisa Nakayama, Jayakar V. Nayak, Peter K. Jackson, Raul Andino, Xiaokun Shu  (2021) PLoS Pathogens (Open Access) (Constructs)
  Imaging dynamic cell signaling in vivo with new classes of fluorescent reporters
  Shu X. (2020) Current Opinion in Chemical Biology (pdf)
  Enhancing intracellular accumulation and target engagement of PROTACs with reversible covalent chemistry
  Wen-Hao Guo, Xiaoli Qi, Xin Yu, Yang Liu, Chan-I Chung, Fang Bai, Xingcheng Lin, Dong Lu, Lingfei Wang, Jianwei Chen, Lynn Hsiao Su, Krystle J. Nomie, Feng Li, Meng C. Wang, Xiaokun Shu, José N. Onuchic, Jennifer A. Woyach, Michael L. Wang, Jin Wang (2020) Nature Communications
  Designing a green fluorogenic protease reporter by flipping a beta strand of GFP for imaging apoptosis in animals
  Zhang Q, Schepis A, Huang H, Yang J, Ma W, Torra J, Zhang SQ, Yang L, Wu H, Nonell S, Dong Z, Kornberg TB, Coughlin SR, Shu X. (2019) J. Am. Chem. Soc. (pdf) (Constructs)
  Dynamic imaging of small molecule induced protein-protein interactions in living cells with a fluorophore phase transition based approach
  Chung CI, Zhang Q, Shu X. (2018) Analytical Chemistry 90, 14287-14293 (pdf) (Constructs)
  Designed peptides that assemble into cross-alpha amyloid-like structures
  Zhang SQ, Huang H, Yang J, Kratochvil HT, Lolicato M, Liu Y, , Shu X*, Liu L*, DeGrado WF* (2018) Nature Chem Biol 14, 870-875 (pdf) (Constructs) (*Co-corresponding author)
  A Rapid Fluorogenic GPCR - Beta-arrestin Interaction Assay (Cover Story)
  Zhang Q, Zheng YW, Coughlin SR, Shu X. (2018) Protein Science 27, 874-879 (pdf) (Constructs)
  Visualizing Dynamics of Cell Signaling In Vivo with a Phase Separation-based Kinase Reporter
  Zhang Q*, Huang H*, Zhang L, Wu R, Chung C, Zhang SQ, Torra J, Schepis A, Coughlin SR, Kornberg TB, Shu X. (2018) Molecular Cell 69, 334-346 (pdf) (Constructs; Transgenic animals) (*Co-first author)
  Precision Optogenetic Tool for Selective Single- and Multiple-cell Ablation in a Live Animal Model System
  Makhijani K*, To TL*, Ruiz-Gonzalez R, Lafaye C, Royant A, Shu X. (2017) Cell Chem Biol. 24, 110-119 (pdf) (Constructs; Transgenic animals) (*Co-first author)
  The Growing and Glowing Toolbox of Fluorescent and Photoactive Proteins (Feature Review)
  Rodriguez EA, Campbell RE, Lin JY, Lin MZ, Miyawaki A, Palmer AE, Shu X, Zhang J, Tsien RY. (2017) Trends Biochem Sci. 42, 111-129 (pdf)
  A Far-red Fluorescent Protein Evolved From a Cyanobacterial Phycobiliprotein
  Rodriguez EA, Tran GN, Gross A, Crisp JL, Shu X, Lin JY, Tsien RY. (2016) Nature Methods 13, 763-769 (pdf)
  Structural Determinants of Improved Fluorescence in a Family of Bacteriophytochrome-based Infrared Fluorescent Proteins: Insights from Continuum Electrostatic Calculations and Molecular Dynamics Simulations
  Feliks M, Lafaye C, Shu X, Royant A, Field M. (2016) Biochemistry 55, 4263-74 (pdf)
  Rational Design of a GFP-based Fluorogenic Caspase Reporter for Imaging Apoptosis in vivo
  To TL, Schepis A, Ruiz-Gonzalez R, Zhang Q, Yu D, Dong Z, Coughlin SR, Shu X. (2016) Cell Chem Biol. 23, 875-882 (pdf) (Constructs)
  Photoactivatable Protein Labeling by Singlet Oxygen Mediated Reactions
  To TL, Medzihradszky KF, Burlingame AL, DeGrado WF, Jo H, Shu X. (2016) Bioorg Med Chem Lett. 26, 3359-3363 (pdf)
  Structure-guided Design of a Reversible Fluorogenic Reporter of Protein-protein Interactions
  To TL, Zhang Q, Shu X. (2016) Protein Science 25, 748-753 (pdf)
  Rational Design of a Monomeric and Photostable Far-red Fluorescent Protein for Fluorescence Imaging In Vivo
  Yu D, Dong Z, Gustafson WC, Ruiz-Gonzalez R, Signor L, Marzocca F, Borel F, Klassen MP, Makhijani K, Royant A, Jan YN, Weiss WA, Guo S, Shu X. (2016) Protein Science 25, 308-315 (available online on Nov. 9, 2015) (pdf) (Reagents: constructs; transgenic animals)
  A Naturally Monomeric Infrared Fluorescent Protein for Protein Labeling in vivo
  Yu D, Baird MA, Allen JR, Howe ES, Klassen MP, Reade A, Makhijani K, Song Y, Liu S, Murthy Z, Zhang SQ, Weiner OD, Kornberg TB, Jan YN, Davidson MW, Shu X. (2015) Nature Methods 12, 763-5 (pdf) (Reagents: constructs; ~40 fusions; transgenic animals)
  A Rationally Designed Infrared Fluorogenic Protease Reporter Visualizes Spatiotemporal Dynamics of Apoptosis in vivo
  To TL, Piggott BJ, Makhijani K, Yu D, Jan YN, Shu X. (2015) PNAS 112, 3338-3343 (pdf) (Reagents: constructs; transgenic animals)
  Singlet oxygen triplet energy transfer-based imaging technology for mapping protein-protein proximity in intact cells
  To TL, Fadul MJ, Shu X. (2014) Nature Communications 5, 4072 (pdf)
  An improved monomeric infrared fluorescent protein for neuronal and tumour brain imaging
  Yu D, Gustafson WC, Han C, Lafaye C, Noirclerc-Savoye M, Ge WP, Thayer DA, Huang H, Kornberg TB, Royant A, Jan LY, Jan YN, Weiss WA, Shu X. (2014) Nature Communications 5, 3626 (pdf) (Reagents)
  Photo-inducible cell ablation in Caenorhabditis elegans using the genetically encoded singlet oxygen generating protein miniSOG
  Qi, Y., Garren, E.J., Shu, X., Tsien, R.Y., Jin, Y. (2012) PNAS 109, 7499-504
  Fluorescent and photo-oxidizing TimeSTAMP tags track protein fates in light and electron microscopy
  Butko MT, Yang J, Geng Y, Kim HJ, Jeon NL, Shu X, Mackey MR, Ellisman MH, Tsien RY, Lin MZ. (2012) Nature Neurosci. 15,1742-51
  A structural basis for the assembly and functions of a viral polymer that inactivates multiple tumor suppressors
  Ou HD, Kwiatkowski W, Deerinck TJ, Noske A, Blain KY, Land HS, Soria C, Powers CJ, May AP, Shu X, Tsien RY, Fitzpatrick JA, Long JA, Ellisman MH, Choe S, O'Shea CC. (2012) Cell 151, 304-19
  A Genetically Encoded Tag for Correlated Light and Electron Microscopy of Intact Cells, Tissues, and Organisms
  Shu, X.; Lev-Ram, V.; Deerinck, T. J.; Qi, Y.; Ramko, E. B.; Davidson, M. W.; Jin, Y.; Ellisman, M. E.; Tsien, R. Y. (2011) PLoS Biol. e1001041
  Mammalian Expression of Infrared Fluorescent Proteins Engineered from a Bacterial Phytochrome
  Shu, X.; Royant, A.; Lin, M. Z.; Aguilera, T.; Lev-Ram, V.; Steinbach, P. A.; Tsien, R. Y. (2009) Science 324, 804-807
  Unique Interactions between the Chromophore and Glutamate 16 Lead to Far-red Emission in a Red Fluorescent Protein (front cover article)
  Shu, X.; Wang, L.; Colip, L.; Kallio, K.; Remington, S. J. (2009) Protein Science 18, 460-466
  An alternative excited state proton transfer pathway in a green fluorescent protein variant S205
  Shu, X.; Leiderman P.; Gepshtein R. Smith N. R.; Kallio K.; Huppert, D.; Remington, S.J. (2007) Protein Science 16, 2703-2710
  Ultrafast Excited State Dynamics in The Green Fluorescent Protein Variant S65T/H148D. 1. Mutagenesis and Structural Studies
  Shu, X.; Kallio, K.; Shi, X.; Abbyad, P.; Kanchanawong, P.; Childs, W.; Boxer, S.G.; Remington, S.J. (2007) Biochemistry 46, 12005-12013
  Ultrafast Excited State Dynamics in The Green Fluorescent Protein Variant S65T/H148D. 2. Unusual Photophysical Properties
  Shi, X.; Abbyad, P.; Shu, X.; Kallio, K.; Kanchanawong, P.; Childs, W.; Remington, S.J.; Boxer, S.G. (2007) Biochemistry 46, 120014-12025
  Ultrafast Excited State Dynamics in The Green Fluorescent Protein Variant S65T/H148D. 3. Short- and Long-time Dynamics of the Excited-state Proton Transfer
  Leiderman P.; Genosar L.; Huppert D.; Shu, X.; Remington, S.J.; Solntsev K.M.; Tolbert L. M. (2007) Biochemistry 46, 120026-12036
  Novel Chromophores and Buried Charges Control Color in mFruits
  Shu, X.; Shaner, N. C.; Yarbrough, C. A.; Tsien, R. Y.; Remington, S. J. (2006) Biochemistry 45, 9639-9647
  Kindling Fluorescent Protein from Anemonia sulcata: Dark-State Structure at 1.38 Å Resolution
  Quillin, M. L.; Anstrom, D. M.; Shu, X.; O'Leary, S.; Kallio, K.; Chudakov, D. M.; Remington, S. J. (2005) Biochemistry 44, 5774-5787
  Surface alloying of immiscible metals induced by surface state shift
  Shu, X.; Jiang, P.; Che, J. (2003) Surface Science 545, 199-210


Laboratory of Xiaokun Shu, PhD | University of California, San Fancisco | Advancing Health Worldwide